In Asder 20-in-1 (BMC-NTD-03 / Mapper 290), SHOOTER PART1 (game #18) requires you to shoot offscreen to reload your gun. Since the Zapper is simulated using the mouse, shooting (clicking) offscreen is not permitted in the emulators that I tested. I'm not even sure how it can be handled if you have a single monitor and the emulator is in fullscreen mode.