Depends on the game and what it does. Also depends whether you want it to play at 6/5 speed or not. If it takes advantage of the extended PAL vblank, you'll probably have a hard time.
Anyhow, start by
learning the difference between NTSC and PAL. If you already know how to program an NES and hack a ROM, it should be fairly clear what you need to do from the differences. If you don't, then you will need to learn that first.
I doubt there's a generic way to describe how to hack PAL to NTSC that you could just take and apply if you aren't already a ROM hacker, and if you are, the wiki page I linked above should be pretty much all you need. The actual steps you need to take will be different for every game. (Some games will even run "ok" if you just put them in the other mode.)
If there is a specific game you are trying to port, let us know your progress, what you have tried, where you are stuck, etc.